LogoChlamydiae Genomes Re-Annotation Initiative

Motivation and concept:

The information about Chlamydiae genomes in the public databases is partially outdated and does not reflect the state of the art in Chlamydiae research. This problem is now really hampering compara­tive analyses, particularly in functional genomics and genetics.

The Chlamydiae Genomes Re-annotation Initiative aims for a community-based re-annotation of all publicly available Chlamydiae genomes. It should be submitted as such to the public databases, re­placing the original annotations. Thereby the whole Chlamydiae research community will bene­fit from up-to-date data e.g. provided by sequence similarity searches and genome data­bases. Furthermore, up-to-date public databases will substantially improve and facilitate future Chlamydiae genome sequencing projects.

Specifically adapted bioinformatic tools will provide a high-quality automatic re-annotation of all publicly available Chlamydiae genomes. This software implements a weighted data integration strategy similar to manual curation. Such re-annotation will not change the numbering (locus tags) of all genes already present in the original annotation (e.g., CT858 will get the gene name CPAF but will keep the locus tag CT858). Manual refinement by the Chlamydiae research community will only need to incorporate specific knowledge from recent literature (and e.g. large-scale omics experiments), and will handle nomenclature issues.

All Chlamydiae researchers are invited to support this initiative and to share their knowledge with the community. Participation will be easy, efficient and adjustable to your availability. All participants will be co-authors on the publication in the end of the project.

In order to sustain database quality, we suggest repeating the re-annotation in regular intervals (e.g. synchronized with the biennial CBRS meetings).

Proposed structure of the project ...

Participate! Join the mailing list:

A mailing list has been created for the Chlamydiae Genomes Re-Annotation Initiative. All relevant information and discussion of the initiative will be communicated via this list. It is technically hosted by the University of Vienna.

Join the online community:

Genome re-annotation session at the 2013 meeting of the Chlamydia Basic Research Society (CBRS) in San Antonio, TX:

Get the material: